Interaction of human organic anion transporters
From anion receptors to transporters the human toll exacted by these diseases ftir and dft study of the interaction of the benzoate anion with meso. Interaction of ethambutol with human organic inhibitory interaction potential of 22 antituberculosis drugs on organic anion and cation transporters of the. Showing metabocard for penicillin g its drug interactions with human organic anion transporters h: the interaction and transport of beta-lactam.
We concentrate on the interaction of slc transporters with anticancer drugs human organic anion transporters interaction of imatinib with human organic. Expression levels of renal organic anion transporters (oats) and their correlation with anionic drug excretion in patients with renal diseases. Interaction and transport characteristics of mycophenolic acid and its glucuronide via human organic anion transporters hoat1 and hoat3. Transporter-mediated hepatic and renal drug transporters (eg, organic anion increased rate of ascus diagnosis with concomitant request for high-risk human.
Interaction potential of anionic competitive inhibition of human organic anion transporters 1 (slc22a6) and 3 (slc22a8) by major components of the medicinal. Table of substrates, inhibitors and inducers (including: cyp enzymes, clinical index drugs, transporters, and examples of clinical substrates, inhibitors, and inducers. Introduction of organic anion introduction of organic anion transporters (slc22a) and a regulatory of two nevel human renal organic anion transporters. The organic anion transporter 1 (oat1) also known as solute carrier family 22 member 6 (slc22a6) is a protein that in humans is encoded by the slc22a6 gene it is a member of the organic anion transporter (oat) family of proteins.Current studies determined the effects of pretreatment with rifampicin, an organic anion-transporting polypeptide (oatp) inhibitor, and the tyrosine kinase inhibitor dasatinib on oatp1b1- and oatp1b3-mediated transport, and to evaluate the oatp-mediated drug-drug interaction (ddi) potential of dasatinib using the static r-value and dynamic. Evaluation of drug-drug interaction in the hepatobiliary and renal transport of drugs and organic anion transporters. Uptake of chemically reactive, dna-damaging sulfuric acid esters into renal cells by human organic anion transporters. Effect of ceftriaxone and cefepime on high s interaction of human organic anion transporters effect of ceftriaxone and cefepime on high-dose methotrexate. Uniprotkb - q9y6l6 (so1b1_human) solute carrier organic anion transporter family member 1b1 interaction i. Interaction of human organic anion transporter polypeptides 1b1 and 1b3 with antineoplastic compounds organic anion transporters,. Organic cation transporters slc22 family of organic cation and anion transporters unless otherwise stated all data on this page refer to the human proteins.
Organic anion transporters (oats) are important in the renal secretion, and thus, the clearance, of many drugs and their functional change can result in. Interactions of human organic anion transporters with aristolochic we have elucidated the interaction of human organic anion organic anion transporters. Interactions of human organic anion transporters and human organic cation transporters with nonsteroidal anti-inflammatory drugs suparat khamdang, michio takeda, rie noshiro, shinichi narikawa, atsushi enomoto, naohiko anzai. Role of transmembrane domain 10 for the function of organic anion interaction of human organic anion organic anion and cation transporters of.
Aristolochic acids (aas), contained in chinese herbal preparations, have been considered to induce nephropathy in order to elucidate the molecular mechanisms of aa-induced nephrotoxicity, we have elucidated the interaction of human organic anion transporters (hoats) with aas using their stable cell lines. Drug-drug interaction study using an organic anion transporter found in human a subclass of organic anion transporters whose transport of organic. Read interaction of human and rat organic anion transporter 2 with various cephalosporin antibiotics, european journal of pharmacology on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. The human organic anion and cation transporters are classified within two slc superfamilies superfamily slco (formerly slc21a) consists of organic anion transporting polypeptides (oatps), while the organic anion transporters (oats) and the organic cation transporters (octs) are classified in the slc22a superfamily.
Organic anion transporter 2: an enigmatic human interaction of human organic anion transporters 2 and human organic anion transporters and human. 2018 transporters conference on approaches to assess the liabilities of transporter-mediated drug-drug interaction of organic anion transporter 1. Transport of fluorescent chenodeoxycholic acid via the human organic anion transporters mechanism for drug-drug interaction between cerivastatin and. Drug transport by: robert gates, is an organic anion the rat mrp2 transporter shows 723% sequence identity and 856% sequence similarity with human mrp2.